Infecciones invasivas por Streptococcus pneumoniae en un hospital pediátrico de tercer nivel antes de la introducción de la vacuna conjugada: Características clínicas y serotipos involucrados / Invasive infections caused by Streptococcus pneumoniae in a terciary care pediatric hospital before the introduction of the conjugate vaccine: Clinical characteristics and serotypes involved
Arch. argent. pediatr
; 111(3): 202-205, jun. 2013. graf, tab
Article
in Spanish
| BINACIS
| ID: bin-130945
Localization: AR1.2
RESUMEN
Las enfermedades invasivas por neumococo constituyen la principal causa de morbimortalidad en los niños. En el Hospital "Prof. Dr. Juan P. Garrahan" se estudiaron retrospectivamente todas las infecciones invasivas por neumococo con hemocultivos positivos entre el 1 de octubre de 2008 y el 30 de septiembre de 2011, antes de la vacunación universal con la vacuna conjugada de 13 serotipos. Se identificaron 124 pacientes, con una media de edad de 48,3 meses (r 1-216). El 58,9% de la población era mayor de 2 años (n 73) y el 89% (n 65) de ellos tenían una enfermedad de base. La principal forma de presentación fue la neumonía. Los serotipos de S. pneumoniae más frecuentes fueron 14 (22,5%, n 25), 6 (14,4%, n 16), 19 (8,1%, n 9), 23 (7,2%, n 8), 1 (6,3%, n 7), 5 (4,5%, n 5) y 7 (7,2%, n 8). El 82,8% de los serotipos de S. pneumoniae de esta serie están incluidos en la vacuna conjugada de 13 serotipos. Es esencial mantener la vigilancia epidemiológica para identificar la evolución y epidemiología de la enfermedad invasiva por neumococo en la Argentina.(AU)
ABSTRACT
Invasive pneumococcal diseases are the main cause of morbidity and mortality in children. In the Hospital "Prof. Dr. Juan P. Garrahan", between October 1st , 2008 and September 30th, 2011 all invasive pneumococcal diseases with positive blood cultures were retrospectively studied before the implementation of the universal immunization schedule with the 13-valent pneumococcal conjugate vaccine. A total of 124 patients were identified, and their mean age was 48.3 months (range 1-216). In this population, 58.9% (n 73) were OVER 2 years old and 89% (n 65) of them had an underlying disease. The most frequent clinical presentation was pneumonia. The most frequent S. pneumoniae serotypes identified were 14 (22.5%, n 25), 6 (14.4%, n 16), 19 (8.1%, n 9), 23 (7.2%, n 8), 1 (6.3%, n 7), 5 (4.5%, n 5), and 7 (7.2%, n 8). Of the S. pneumoniae serotypes in this series, 82.2% is included in the 13-valent pneumococcal conjugate vaccine. Continuous epidemiological surveillance is essential to further identify the epidemiology and study the evolution of invasive pneumococcal disease in Argentina.(AU)
Full text:
Available
Collection:
National databases
/
Argentina
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 10: Communicable diseases
Database:
BINACIS
Main subject:
Pneumococcal Infections
/
Streptococcus pneumoniae
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Language:
Spanish
Journal:
Arch. argent. pediatr
Year:
2013
Document type:
Article
Institution/Affiliation country:
Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan/s.p