Deficiencia de micronutrientes y enfermedad celíaca en pediatría. / [Micronutrient deficiencies and celiac disease in Pediatrics].
Arch Argent Pediatr
; 112(5): 457-63, 2014 Oct.
Article
in Spanish
| BINACIS
| ID: bin-133475
ABSTRACT
Celiac disease (CD) is apparently changing in its clinical presentation, from chronic diarrhea and malnutrition to a silent clinic at older ages. The basal enteropathy of CD induces macro-and micronutrient malabsorption. Described micronutrient deficiencies in CD include Fe, Zn, Cu, folate, Ca, vitamin E, D, B12 and B6, with complex transporter mechanisms altered. Ferropenic anemia has been described in CD as the exclusive sign and the most common extraintestinal sign. Zn deficiency is frequent in CD, associated with growth delay and immune alterations. Even though the main basis for vitamin D metabolic status is the activation of subdermal vitamin precursors by sun-UVB rays, the small bowel compromise may affect activity and vitamin D absorption. Pathophysiology of vitamin B12 deficiency in CD is unknown; it must be suspected in CD patients presenting neurological and haematological alterations. Copper deficiency has been described mainly in adult CD patients. Micronutrient deficiencies should be periodically studied through the CD follow-up; celiac disease must be studied if clinical signs of micronutrient deficiencies are diagnosed.
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Full text:
Available
Collection:
International databases
/
National databases
/
Argentina
Health context:
Neglected Diseases
Health problem:
Diarrhea
Database:
BINACIS
/
LILACS
Main subject:
Celiac Disease
/
Micronutrients
Type of study:
Etiology study
Limits:
Child
/
Humans
Language:
Spanish
Journal:
Arch Argent Pediatr
/
Arch. argent. pediatr
Journal subject:
Pediatrics
Year:
2014
Document type:
Article
Affiliation country:
Chile
Institution/Affiliation country:
Universidad de Chile/CL