Murine splenic proliferative response to human recombinant erythropoietin along hypoxia.
Acta Physiol. Pharmacol. Ther Latinoam
; 45(2): 97-103, 1995.
Article
in English
| BINACIS
| ID: bin-37209
Responsible library:
AR1.1
ABSTRACT
Hypoxia is the best physiological stress to disturb the erythropoietic steady state. The present study has been undertaken in the aim to analize the splenic erythropoietic proliferative response with different doses of recombinant human erythropoietin under hypoxic conditions along 18 days using the DNA synthesis assay. Normoxic splenic progenitors failed to show significative erythroid replication at 0 days. A clearly rh Epo response was noticed from 2 to 8 days of hypoxia. Splenic proliferation returned to basal pattern from 10 days to the end of the experience. The highest proliferative activity, 25 fold increase over control (p < 0.001), was found at 6 days from 62.5 to 250 mU/ml rh Epo. These results support suggestions that hypoxia induces a transiently erythroid splenic proliferative response changing its quantitative parameters in the Epo dose-response relationship during the physiological adaptation.
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Collection:
National databases
/
Argentina
Database:
BINACIS
Language:
English
Journal:
Acta Physiol. Pharmacol. Ther Latinoam
Year:
1995
Document type:
Article