Chronic indomethacin administration and its relation with the renal kallikrein kinin system during rat pregnancy.

Oddo, E M; Negri, A L; Santos, J C; Martín, R S; Arrizurieta, E E

Oddo, E M; Negri, A L; Santos, J C; Martín, R S; Arrizurieta, E E.

Affiliation

Arrizurieta, E E; Laboratorio de Nefrología Experimental, Instituto de Investigaciones Médicas Alfredo Lanari, Facultad de Medicina, Universidad de Buenos Aires, Argentina..

Medicina [B Aires] ; 53(4): 326-32, 1993.

Article in English | BINACIS | ID: bin-37687

Responsible library: AR2.1

ABSTRACT

ABSTRACT

The main purpose of the present study was to elucidate the potential role of vasodilator prostaglandins and the kallikrein kinin system in renal hemodynamic changes observed during rat gestation. Nineteen pregnant rats, un-treated and treated with Indomethacin (3 mg/kg body/wt) for 4 days during peak glomerular hyperfiltration, were studied before and during pregnancy. Twenty-two non-pregnant rats were also included as controls. Daily urinary volume, electrolytes and kallikrein excretion and creatinine clearance were measured along the experiment. Baseline creatinine clearance increased by 43

Search on Google

Add to My VHL

XML

Collection: National databases / Argentina Database: BINACIS Language: English Journal: Medicina [B Aires] Year: 1993 Document type: Article

Search on Google

Add to My VHL

XML

Collection: National databases / Argentina Database: BINACIS Language: English Journal: Medicina [B Aires] Year: 1993 Document type: Article