Vaciamiento gástrico de líquidos en ratas sometidas a infarto del miocardio. / [Gastric emptying of liquids in rats submitted to acute myocardial infarction]

ABSTRACT

Gastric Emptying (GE) is food transition from the stomach to the upper small intestine. Haemodynamics changes modify gastric emptying and the gastroduodenal motor activity. Myocardial Infarction is a pathological condition in which there are haemodynamics changes. Therefore, the objective of the present investigation was to study the effect of acute myocardial infarction on rat gastric emptying of an isosmotic and inert liquid meal. We conducted a study involving male Wistar rats (varying in body weight from 220 g to 250 g), that were allowed to habituate in a laboratory environment and then divided into 3 groups group INF, rats in which the myocardial infarction was produced by left anterior coronary artery ligation; group SH, rats in which the myocardial infarction was simulated without ligating the anterior coronary artery; and group NA, rats which were not given any anesthesia or surgical procedures. After group constitution, animals were fasted with access to water ad libitum. 24 hours later, the Gastric Retention (GR) of 1.5 ml/100 g animal weight of a test meal of 0.9