Virucidal activity presence in Trichilia glabra leaves.
Rev. argent. microbiol
; 36(3): 136-8, 2004 Jul-Sep.
Article
in English
| BINACIS
| ID: bin-38577
Responsible library:
AR32.1
ABSTRACT
Different immunomodulatory activities present in Trichilia glabra (TG) leaf extracts have already been described. Particularly, chloroform-methanol extracts were responsible for an in-vivo anti-inflammatory effect. The effect of such extracts on the infectivity of enveloped and naked viruses were investigated. Methanolic fraction extracts were active against herpes simplex virus type 1 (HSV-1) and vesicular stomatitis virus (VSV), while no activity against poliovirus type 3 was observed. VSV was slightly more affected than HSV-1 2.8 log10 reduction in VSV titer against 2.4 log10 reduction in HSV-1 titer when 0.25 mg/ml F2 fraction was tested and a reduction of 2.7 log10 in VSV virus titer and of 1.5 log10 in HSV-1 virus titer was observed when 0.25 mg/ml F3 fraction was tested. Results obtained in this work suggest a potential pharmaceutical use of TG extract components.
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Collection:
National databases
/
Argentina
Database:
BINACIS
Language:
English
Journal:
Rev. argent. microbiol
Year:
2004
Document type:
Article