La dicotomía de los virus polioma. Infección lítica o inducción de neoplasias? / [The paradox of polyomaviruses. Lytic infection or tumor induction?]
Medicina [B Aires]
; 64(1): 73-6, 2004.
Article
in Spanish
| BINACIS
| ID: bin-38730
Responsible library:
AR2.1
ABSTRACT
Murine polyomaviruses can produce lytic infections in mouse cell cultures or transform in vitro rat fibroblasts through a complex interaction with key cellular regulators. After infection of newborn mice, some strains of polyomavirus induce epithelial and mesenchymal tumors. It has been described that there is a direct relationship between viral dissemination in the mouse and tumor induction. However, at a single cell level lytic infection and transformation would not be able to coexist. The existence of 3 distinct cell populations in polyoma-induced tumors, classified according to the presence or absence of viral DNA and viral capsid protein VP-1 have been described. We have reported a fourth type of cell in the neoplasms, that can express the early and the late viral genes but do not allow virus assembly, probably due to underphosphorylation of VP-1. The mechanisms of polyoma intracellular migration and dissemination in the mouse are discussed, related to the virus ability of tumor induction.
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Collection:
National databases
/
Argentina
Database:
BINACIS
Language:
Spanish
Journal:
Medicina [B Aires]
Year:
2004
Document type:
Article