Importancia pronóstica de la expresion de MDR-1 en la leucemia mieloblástica aguda. / [Prognostic value of the expression of MDR-1 in acute myeloid leukemia]
Medicina [B Aires]
; 63(4): 277-82, 2003.
Article
in Spanish
| BINACIS
| ID: bin-38893
Responsible library:
AR2.1
ABSTRACT
An important number of patients with Acute Myeloid Leukemia (AML) experience relapse or resistance to chemotherapy. One of the mechanisms involved in this resistance is the presence of glycoprotein P170 (gp-P 170), which results of the MDR-1 gene in leukemic cells. The objective of this article is to assess the prognostic impact of the expression of MDR-1 in a group of patients treated for AML. The expression of MDR-1 was retrospectively assessed in a cohort of 55 patients with AML, older than 16 years old, who received chemotherapy from 1990 to 2000. The presence of MDR-1/gp-P170 was evaluated on bone marrow biopsy by immunohisto-chemistry. A ROC curve established that an expression of > 50
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Collection:
National databases
/
Argentina
Database:
BINACIS
Type of study:
Prognostic study
Language:
Spanish
Journal:
Medicina [B Aires]
Year:
2003
Document type:
Article
