Evolución de la leucemia linfática crónica. Valor predictivo del inmunofenotipo, el CD23 soluble y la morfología. / [Evolution of chronic lymphocytic leukemia: predictive value of immunophenotype, soluble CD23 and morphology]
Medicina [B Aires]
; 62(4): 305-12, 2002.
Article
in Spanish
| BINACIS
| ID: bin-39146
Responsible library:
AR2.1
ABSTRACT
Some prognostic factors are useful in chronic lymphocytic leukemia (CLL) lymphocyte doubling time, clinical stage and bone marrow pattern infiltration, while others, such as the percentage of CD38+ cells, are under study and require confirmation. The objective of this study was to evaluate whether there is an association between morphology, lymphocyte immunophenotype, soluble CD23 (sCD23) and progression free survival (PFS). A total of 36 non-treated patients were enrolled. We analysed prospectively morphology (typical, mixed and PL-CLL); immunophenotypic profile (Matutes score); sCD23 plasma levels; clinical stage; lymphocyte doubling time; beta 2 microglobulin and karyotype abnormalities. Disease progression (need of treatment, progression to advanced stages, development of bulky organomegaly) and death related to disease were considered as events. Md of follow-up 24 mo. RESULTS:
Stage 0 11/36, PFS 80
Search on Google
Collection:
National databases
/
Argentina
Database:
BINACIS
Type of study:
Prognostic study
/
Risk factors
Language:
Spanish
Journal:
Medicina [B Aires]
Year:
2002
Document type:
Article
