Immunologic and genetic markers in insulin-dependent diabetes mellitus (type 1) in an Argentine population.

Krochik, A G; Mazza, C S; Valdez, S N; Stumpo, R R; Papouchado, M L; Iacono, R F; Cardoso Landaburu, A C; Sica, M P; Ozuna, B; Poskus, E

Krochik, A G; Mazza, C S; Valdez, S N; Stumpo, R R; Papouchado, M L; Iacono, R F; Cardoso Landaburu, A C; Sica, M P; Ozuna, B; Poskus, E.

Affiliation

Poskus, E; Servicio de Nutrición, Hospital Nacional de Pediatría Juan P. Garrahan, Buenos Aires..

Medicina [B Aires] ; 61(3): 279-83, 2001.

Article in English | BINACIS | ID: bin-39497

Responsible library: AR2.1

ABSTRACT

ABSTRACT

The objective was to evaluate the prevalence and association of several markers (islet cell antibodies ICA, insulin autoantibodies IAA, glutamic acid decarboxylase antibodies GADA and ICA512 antibodies ICA512A) along with HLA DQB1 genotype in type 1 diabetes mellitus of recent onset, including siblings and individuals without any history of this disease, in an Argentine population. A total of 79 children with type 1 diabetes mellitus of recent onset were studied, as well as 79 control children, and 68 healthy siblings of type 1 diabetic cases. IAA, ICA, GADA, ICA512A and HLA DQB1 alleles were determined. Sensitivity was 67.1

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Collection: National databases / Argentina Database: BINACIS Type of study: Prognostic study / Risk factors Country/Region as subject: South America / Argentina Language: English Journal: Medicina [B Aires] Year: 2001 Document type: Article

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