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El intercambiador Na+/Ca2+ como responsable del atontamiento miocárdico. / [The Na+/Ca2+ exchanger as responsible for myocardial stunning]
Mosca, S M; Cingolani, H E.
Affiliation
  • Cingolani, H E; Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina..
Medicina [B Aires] ; 61(2): 167-73, 2001.
Article in Spanish | BINACIS | ID: bin-39543
Responsible library: AR2.1
ABSTRACT
Our objective was to assess the participation of Na+/H+ exchanger (NHE) and Na+/Ca2+ exchanger (NCX) on systolic and diastolic alterations of myocardial stunning. Isolated perfused rat hearts were submitted to 20 min of global ischemia (Is) followed by 30 min of reperfusion (R). This protocol was repeated after treatment before ischemia and/or early in R. with HOE 642 1 microM, a specific blocker of NHE-1 and KB-R7943 1 microM the novel inhibitor of the reverse mode of NCX. In control ischemic hearts the contractility assessed through +dP/dtmax recovered approximately 60
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Collection: National databases / Argentina Database: BINACIS Type of study: Practice guideline Language: Spanish Journal: Medicina [B Aires] Year: 2001 Document type: Article
Search on Google
Add to My VHL
Print
XML
Collection: National databases / Argentina Database: BINACIS Type of study: Practice guideline Language: Spanish Journal: Medicina [B Aires] Year: 2001 Document type: Article