Celecoxib vs indometacina y lesiones gástricas agudas en ratas. / [Celecoxib vs indomethacin and acute gastric lesions in rats]
Medicina [B Aires]
; 60(2): 221-4, 2000.
Article
in Spanish
| BINACIS
| ID: bin-39834
Responsible library:
AR2.1
ABSTRACT
In 5 random groups of Wistar rats (n = 15 for each group), ulcerogenic doses of NSAIDs COX-1-COX-2 inhibitors such as indomethacin were compared with Celecoxib (COX-2 inhibitor); the production of antrum gastric ulcers and bowel and colon necrotic areas was studied. Celecoxib was given each 12 hs orally and subcutaneously during 5 days and gastrointestinal lesions were not found; in contrast, Celecoxib given after indomethacin aggravated antrum gastric ulcers (p < 0.001); intestinal massive necrosis and death were observed in all the rats. We conclude that Celecoxib does not induce gastrointestinal lesions in healthy mucosa; in contrast, Celecoxib amplifies the gastrointestinal lesions induced by indomethacin.
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Collection:
National databases
/
Argentina
Database:
BINACIS
Language:
Spanish
Journal:
Medicina [B Aires]
Year:
2000
Document type:
Article