La importancia de los auto-anticuerpos IgG, específicos anticolágeno tipo II en la enfermedad de MeniÞre y pérdida progresiva de la audición. / [The importance of IgG auto-antibodies, anti-collagen type II specific in MeniÞres disease and progressive hearing loss]

ABSTRACT

The Menieres Disease and Progressive Hearing Loss were considered idiopathic. Both entities were produced by endo lymphatic hydrops and disruption of the membrane which contain type II collagen. The inner ear presented widely expression of type II collagen. These pathologies were probably autoimmune diseases. The aim of this work was to study the relationship of specific IgG to type II collagen in Menieres disease, Progressive hearing loss, and compared with Sudden hearing loss patients, vascular vertigo patients and normal controls. Patients were divided by clinical findings in 1 degree Menieres disease (n27), 2 degrees Progressive Hearing loss (n20), 3 degrees Sudden hearing loss (n15), 4 degrees Vascular Vertigo (n9) and compared with normal controls (n30) aged and sex matched. We have measured specific IgG to type II collagen by ELISA test. We considered positive the OD two or more SD above the mean of normal controls. RESULTS: 1 degree The Menieres group presented IgG to type II collagen (+) in 22 out of 27 patients, p < .025; 2 degrees The Progressive Hearing loss presented IgG to type II collagen in all cases (n20), p < .0005. The Sudden Hearing loss presented IgG to type II collagen (-) in all cases (n15) p < .00001 and Vascular Vertigo (n9) presented IgG to type II collagen (-) in 8 out of 9 cases, p < .0005. These results suggest strongly the notion that Menieres diseases and Progressive hearing loss have specific IgG to type II collagen and these conditions were ascribed with in autoimmune process.