Transplantation of islets of Langerhans in diabetic rats.
Acta Physiol Lat Am
; 27(1): 1-6, 1977.
Article
in English
| BINACIS
| ID: bin-47799
Responsible library:
AR1.1
ABSTRACT
In the present work, homogeneous isolated pancreatic islet-cells were transplanted to diabetic rats with the aim of verifying if the transplanted tissue could survive and reduce the plasma glucose concentration on the alloxan-induced diabetic receptors. For the isolation of the pancreatic islets, pancreas was incubated in collagenase solution for about 13 +/- 3 minutes, followed by centrifugation in Ficoll gradients. The islets, 3 000 to 5 000, were transplanted to alloxan diabetic recipients, in a territory, preferentially with portal-hepatic drainage (mesentery and spleen). Sixty per cent of the recipients exhibited a fall of the plasma glucose concentration, up to 70
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Collection:
National databases
/
Argentina
Database:
BINACIS
Language:
English
/
Spanish
Journal:
Acta Physiol Lat Am
/
Acta physiol. latinoam
Year:
1977
Document type:
Article