Evolución de prolactinomas en adolescentes. / [The course of prolactinomas in adolescents]

ABSTRACT

Results of treatment and long and short-term follow up of 13 patients (8 girls, 5 boys), aged 14-20 years (x16.5) with prolactinomas, were assessed. Most frequent initial symptoms were cephalea, puberty arrest or delay, galactorrhea and visual impairment. Pre-treatment evaluation showed variable and discordant responses of LH and FSH to LR-RH test, while results of TRH (TSH) test were normal in 8/9 patients (one girl had a primary hypothyroidism). Basal prolactin (PRL) levels were high in all patients (77 and 1150 ng/ml; mean +/- SD 378 +/- 285), without further increase of TRH (mean 25