Infección intracerebral de ratones atímicos con una cepa atenuada de virus Junín. / [Intracerebral infection of athymic mice with an attenuated strain of Junín virus]
Rev. argent. microbiol
; Rev. argent. microbiol;22(3): 150-4, 1990 Jul-Sep.
Article
in Es
| BINACIS
| ID: bin-51567
Responsible library:
AR32.1
ABSTRACT
Infection of newborn immunocompetent (nu/+) mice with the XJ prototype strain of Junin virus, etiological agent of Argentine Hemorrhagic Fever, produces a lethal meningo-encephalitis due to cellular immune response. The same strain inoculated into athymic (nu/nu) mice produces an asymptomatic persistent infection. The purpose of this work was to determine the nu/nu mice response when infected with XJCl3, an attenuated Junin virus strain, since this strain behaves differently to the pathogenic prototype in various experimental hosts and humans. Fifty five suckling nu/nu mice and 45 nu/+ were inoculated intracerebrally with 10(3) PFU of the XJCl3 strain. Twenty nu/nu and 20 nu/+ were kept as uninoculated controls. Similar percentages of mortality were recorded for nu/nu and nu/+ infected animals (86 and 87
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Collection:
06-national
/
AR
Database:
BINACIS
Language:
Es
Journal:
Rev. argent. microbiol
Year:
1990
Document type:
Article
Country of publication:
Argentina