Actividad de cefpiroma sobre bacterias aisladas de pacientes internados. / [Activity of cefpirome against bacteria isolated from hospitalized patients]

ABSTRACT

The activity of cefpirome (HR 810) was evaluated against 247 strains isolated from patients developing their infections while in a hospital in Buenos Aires. Its activity against Gram negative bacilli was compared with ceftriaxone, ceftazidime, cephalotin, piperacillin, amikacin, gentamicin and norfloxacin. In terms of MIC50 and MIC90 (mg/l) it was as follows Klebsiella pneumoniae less than 0.125, less than 2.0; Pseudomonas aeruginosa less than 8, less than 16; Escherichia coli less than 0.016, less than 0.063; Serratia marcescens less than 0.063, less than 1.0; Enterobacter cloacae less than 0.125, less than 1.0. Cefpirome was more active than the other cephalosporins against P. aeruginosa at 16 mg/l, this drug inhibited 95