A randomized controlled trial comparing split and subunit influenza vaccines in adults in Colombia
Medicina [B.Aires]
; 63(3): 197-204, 2003. tab, graf
Article
in English
| BINACIS
| ID: bin-5776
Responsible library:
BR1.1
ABSTRACT
In a two-center, comparative trial, 344 adults were randomly assigned to receive a single dose of inactivated split-virion (Imovax Gripe) or sub-unit (Agripal S1) influenza vaccine (1999-2000 formulations). For analysis, study groups were subdivided into adult (18-60 years old) and elderly (over 60 years) subjects. Blood was drawn immediately before and one month after vaccination, safety was evaluated using a blind-observer design based on reporting of solicited and unsolicited adverse events. Both vaccines were very well torelated, had similar reactogenicity profiles, and elicited fewer reports of reactions in elderly individuals. Post-vaccination Imovax Gripe induced seroprotective antibody titers against the three vaccine strains in 94-99% of adults and 88-97% od elderly subjects, compared with 88-100% and 88-98%, respectively, of those given Agrippal S1. In conclusion, the split-virion and sub-unit influenza had similar safety and reactogenicity profiles, and elicited satisfactory immunuty in adult and elderly subjects. However, higher post-vaccination geometric mean titer (GMT) values in response to the B strain were seen with the split vaccine Imovax Gripe, giving it a better overall immunogenicity.(AU)
Full text:
Available
Collection:
National databases
/
Argentina
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
BINACIS
Main subject:
Influenza Vaccines
/
Influenza, Human
Type of study:
Controlled clinical trial
Limits:
Adolescent
/
Adult
/
Aged
/
Aged, 80 and over
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Medicina [B.Aires]
Year:
2003
Document type:
Article
Institution/Affiliation country:
Aventis Pasteur International/France
/
Centro Médico Los Andes/s.p
/
Siplas LTDA/Colombia