Development of an enzyme-linked immunosorbent assay for diagnosis of human herpesvirus-7 infection
Rev Soc Bras Med Trop, v. 53, e20190181, mar. 2020
Article
in English
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP
| ID: bud-2977
Responsible library:
BR78.1
ABSTRACT
INTRODUCTION:
Human herpesvirus (HHV)-7 establishes a latent infection during the lifetime of the host and can reactivate after the primary infection, leading to lytic replication in immunosuppressed patients.METHODS:
This study aimed to develop an enzyme-linked immunosorbent assay (ELISA) to identify HHV-7 serum antibodies and compare its performance with that of an indirect immunofluorescence assay (IFA).RESULTS:
Serum samples (n=102) were tested by IgG-IFA and by ELISA. IFA and ELISA showed IgG-positive results in 77 and 73 samples, respectively. Qualitative concordance of 96% was demonstrated between the two techniques.CONCLUSIONS:
ELISA may be useful to diagnose HHV-7 infection.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IBPROD
Type of study:
Diagnostic study
/
Qualitative research
Language:
English
Journal:
Rev Soc Bras Med Trop
Year:
2020
Document type:
Article