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Inhibition of severe acute respiratory syndrome coronavirus 2 replication by hypertonic saline solution in lung and kidney epithelial cells
ACS Pharmacol Transl Sci, v. 5, n. 4, p. 1514–1527, set. 2021
Article in English | Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP | ID: bud-3992
Responsible library: BR78.1
ABSTRACT
An unprecedented global health crisis has been caused by a new virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We performed experiments to test if a hypertonic saline solution was capable of inhibiting virus replication. Our data show that 1.2% NaCl inhibited virus replication by 90%, achieving 100% of inhibition at 1.5% in the nonhuman primate kidney cell line Vero, and 1.1% of NaCl was sufficient to inhibit the virus replication by 88% in human epithelial lung cell line Calu-3. Furthermore, our results indicate that the inhibition is due to an intracellular mechanism and not to the dissociation of the spike SARS-CoV-2 protein and its human receptor. NaCl depolarizes the plasma membrane causing a low energy state (high ADP/ATP concentration ratio) without impairing mitochondrial function, supposedly associated with the inhibition of the SARS-CoV-2 life cycle. Membrane depolarization and intracellular energy deprivation are possible mechanisms by which the hypertonic saline solution efficiently prevents virus replication in vitro assays.


Full text: Available Collection: National databases / Brazil Health context: SDG3 - Health and Well-Being Health problem: Target 3.8 Achieve universal access to health Database: Sec. Est. Saúde SP / SESSP-IBPROD Language: English Journal: ACS Pharmacol Transl Sci Year: 2021 Document type: Article

Full text: Available Collection: National databases / Brazil Health context: SDG3 - Health and Well-Being Health problem: Target 3.8 Achieve universal access to health Database: Sec. Est. Saúde SP / SESSP-IBPROD Language: English Journal: ACS Pharmacol Transl Sci Year: 2021 Document type: Article
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