G protein subunit Beta 3 (GNB3) variant is associated with biochemical changes in brazilian patients with Hypertension
Arq Bras Cardiol, v. 120, n. 12, e20230396, set. 2023.
Article
in English
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP
| ID: bud-5256
Responsible library:
BR78.1
ABSTRACT
Background:
Genes and their variants associated with environmental factors contribute to the development of the hypertensive phenotype. The G protein beta 3 subunit gene (GNB3) is involved in the intracellular signaling process, and its variants have been related to susceptibility to arterial hypertension.Objective:
To determine the association of the GNB3 variant (rs5443C>T) with arterial hypertension, biochemical parameters, age, and obesity in hypertensive and normotensive individuals from Ouro Preto, Minas Gerais, Brazil.Method:
The identification of variants was performed by real-time PCR, using the TaqMan® system, in 310 samples (155 hypertensive and 155 normotensive). Biochemical analyses (renal function, lipid profile and glycemia) were performed from the serum using UV/Vis spectrophotometry and ion-selective electrode. A multiple logistic regression model was used to identify factors associated with arterial hypertension. The analysis of continuous variables with normal distribution was performed using the unpaired Student’s t test; non-normal data were analyzed using Mann Whitney. P < 0.05 was considered significant.Results:
The rs5443C>T variant was not associated with arterial hypertension in the evaluated population (p = 0.88). Regarding biochemical measures, the T allele was associated with high levels of triglycerides, glucose and uric acid in hypertensive individuals (p < 0.05).Conclusion:
These results show the importance of genetic diagnosis to prevent the causes and consequences of diseases and imply that the GNB3 rs5443C>T variant may be associated with changes in the biochemical profile in hypertensive individuals.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IBPROD
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Arq Bras Cardiol
Year:
2023
Document type:
Article