Genetics and metabolic deregulation following cancer initiation: A world to explore
Biomed. Pharmacother
; 82: p. 449-458, 2016.
Article
| Sec. Est. Saúde SP, SESSP-IBPROD, Sec. Est. Saúde SP
| ID: but-ib14540
Responsible library:
BR78.1
Localization: BR78.1
ABSTRACT
Cancer is a group of highly complex and heterogeneous diseases with several causes. According to the stochastic model, cancer initiates from mutation in somatic cells, leading to genomic instability and cell transformation. This canonical pathway of carcinogenesis is related to the discovery of important mechanisms that regulate cancer initiation. However, there are few studies describing genetic and metabolic alterations that deregulate transformed cells, resulting in epithelial-mesenchymal transition (EMT) and its most dramatic consequence, the metastasis. This review summarizes the main genetics and metabolic changes induced by reactive oxygen species (ROS) that lead to EMT. (C) 2016 Elsevier Masson SAS. All rights reserved.
Full text:
Available
Collection:
National databases
/
Brazil
Database:
Sec. Est. Saúde SP
/
SESSP-IBPROD
Main subject:
Genetics
/
Medical Oncology
Journal:
Biomed. Pharmacother
Year:
2016
Document type:
Article