Can Cerebrolysin influence chronic deterioration of spatial learning and memory

ABSTRACT

Summary. Our previous studies showed that the nootropic drugs CEREBROLYSIN, applied immediately after the traumatic or excitotoxic brain lesions influenced spatial learning and memory. Long-lasting ameliorative effects of CEREBROLYSIN was found after its 4-week-administration, while 2-week-treatment had only temporal effect. With the aim to verify the capability of CEREBROLYSIN to restore chronically deterioratedlearning and memory. The drug was applied 4 months after lesioning the rat's CNS. The present study shows that CEREBROLYSIN restored learning capability of the lesioned rats. Although their spatial memory was improved in comparison to lesion untreated controls, it did not reach the level of intact controls. The effects was more pronounced after the application of 1.25 ml/kg b.w. of CEREBROLYSIN than after the application of 2.5 ml/kg b.w.(AU)