NGF prevents changes in rat brain glutathione-related enzymes following transection of the septohippocampal pathway
La Habana; s.n; 1999. 6 p. graf.
Non-conventional
in English
| CUMED
| ID: cum-16425
Responsible library:
CU1
Localization: Centro Internacional de Restauración Neurológica
ABSTRACT
The activities of the enzymes glutathione reductase (GRD), glutathione peroxidase (GPX), and glutathione S-transferase (GST) were studied in several rat brain areas following the aspirative transection of the septohippocampal pathway (fimbria fornix) and the administration of nerve growth factor (NGF) or cytochrome c. One group of animals remained untreated. This lesion resulted in a decreased hippocampal GRD and septal GST activities, as well as, in an increase in GPX activity from the frontal cortex, striatum, and septum, NGF prevented the lesion-induced changes in hippocampal GRD and septal GPX. These findings show that the insult resulting from the aspiration of the fimbria fornix bundle involves modifications in glutathione-related enzymes, and, therefore, in the antioxidant status of brain tissue. These changes in gluthatione metabolism could be a consequence of the oxidative damage to GRD and GST protein or represent a compensatory response of GPX to the oxidative threat. The restirubg effects if BGF ib aktered ebztne activities are possibly linked to its known neuroprotective action(AU)
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Collection:
National databases
/
Cuba
Database:
CUMED
Main subject:
Rats
/
Disease Models, Animal
/
Glutathione
/
Hippocampus
/
Nerve Growth Factors
Type of study:
Prognostic study
Language:
English
Year:
1999
Document type:
Non-conventional