Immunological study in Parkinson's disease patients with intracerebral allografts

ABSTRACT

Immunological response was characterized in 15 patients with Parkinso's disease intracerebrally transplanted seven in unilateral and eight in bilateral hemisphere with fetal mesencephalic cells by stereotactical technique. The phenotypic distribution of mononuclear cells in CSF and PB was investigated using monoclonal antibodies. The total protein, albumin and IgG in CSF and albumin, IgA, IgM and IgG Concentration in serum were also analyzed, before and after evolution. A general decrease in CD2+ cells was found in patients with unilateral neurotransplantation during the first semester following trasplant. A small increase in the proportion of CSF CD8+ cells was observed in the first month and in the fourth month in PB. In patients with bilateral intracerebral allografts a decrease in CD2+ and CD4+ cells was found during the first and fourth month. The intrathecal synthesis of IgG during the fourth month was observed in both patients. Results are discussed taking into account the immunosupressor treatment(AU)