Nerve growth factor and striatal glutathione metabolism in a rat model of Huntingtonïs disease

ABSTRACT

Purpose. To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. Methods. Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. Resuts. NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. Conclusions. NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism(AU)