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Saccade Velocity isControlled by PolyglutamineSize in SpinocerebellarAtaxia 2
Velàzquez-Pèrez, Luis; Seifried, Carola; Santos-Falcòn, Nieves; Abele, Michael; Ziemann, Ulf; Almaguer, Luis Enrique; Martìnez-Gòngora, Edilberto; Sànchez-Cruz, Gilberto; Canales, Nalia; Pèrez-Gonzàlez, Ruth; Velàzquez-Manresa, Mercedes.
Affiliation
  • Velàzquez-Pèrez, Luis; Clìnica para la Investigaciòn y Rehabilitaciòn de las Ataxias Hereditarias. Holguìn. Cuba
  • Seifried, Carola; Clinic for Neurology, University. Frankfurt. Germany
  • Santos-Falcòn, Nieves; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Abele, Michael; University Hospital Bonn. Bonn. Germany
  • Ziemann, Ulf; Clinic for Neurology, University. Frankfurt. Germany
  • Almaguer, Luis Enrique; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Martìnez-Gòngora, Edilberto; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Sànchez-Cruz, Gilberto; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Canales, Nalia; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Pèrez-Gonzàlez, Ruth; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
  • Velàzquez-Manresa, Mercedes; Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias. Holguìn. Cuba
Ann Neurol ; 56: 444-447, 2004. graf
Article in English | CUMED | ID: cum-36614
Responsible library: CU422.1
Localization: CU422.1
ABSTRACT
We assessed maximal saccade velocity (MSV) in 82 spinocerebellarataxia type 2 (SCA2) patients and 80 controls,correlating it to disease duration, polyglutamine expansionsize, age at onset, ataxia score, age, and sex. Littleoverlap with normal values was found even at earlieststages. Stepwise linear regression analysis showed that 60-degree MSV was strongly influenced by polyglutaminesize and less by disease duration, whereas the reverse wasfound for ataxia score. Saccade velocity thus is a sensitive,quite specific, and objective endophenotype, useful tosearch polyglutamine modifier genes...(AU)
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Collection: National databases / Cuba Database: CUMED Main subject: Spinocerebellar Ataxias / Dysarthria Limits: Humans Language: English Journal: Ann Neurol Year: 2004 Document type: Article Institution/Affiliation country: Clinic for Neurology, University/Germany / Clìnica para la Investigaciòn y Rehabilitaciòn de las Ataxias Hereditarias/Cuba / Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias/Cuba / University Hospital Bonn/Germany
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Collection: National databases / Cuba Database: CUMED Main subject: Spinocerebellar Ataxias / Dysarthria Limits: Humans Language: English Journal: Ann Neurol Year: 2004 Document type: Article Institution/Affiliation country: Clinic for Neurology, University/Germany / Clìnica para la Investigaciòn y Rehabilitaciòn de las Ataxias Hereditarias/Cuba / Clìnica para la Investigaciòn y Rehabilitaciòn de las AtaxiasHereditarias/Cuba / University Hospital Bonn/Germany