IL-10 levels in Dengue patients: some findings from the exceptional epidemiological conditions in Cuba
J med virol
; 73(2): 230-234, jun. 2004. tab
Article
in English
| CUMED
| ID: cum-38650
Responsible library:
CU418.1
ABSTRACT
The pathogenesis associated with Dengue haemorrhagic fever, has yet to be fully elucidated, with no definitive in vivo evidence. The exceptional epidemiological circumstances in Cuba allow the evaluation of different mediators in a well-defined situation. In the present study, we describe the determination of levels of IL-12, IL-10 and RANTES in the sera of Cuban patients hospitalised with Dengue fever or Dengue haemorrhagic fever. The results showed that levels of serum IL-10 were higher in patients than controls, and those patients with secondary infections had consistently higher levels. All the Dengue haemorrhagic fever patients had increased levels of IL-10. In contrast, levels of IL-12 did not differ between patients and controls. Finally, RANTES serum levels detected in patients were lower than those observed in the controls. The association of increased levels of IL-10 in Dengue patients with a sequential infection suggests a possible role of this cytokine in the pathogenesis of Dengue disease (AU)
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Collection:
National databases
/
Cuba
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Dengue
/
Neglected Diseases
Database:
CUMED
Main subject:
Cytokines
/
Chemokine CCL5
/
Severe Dengue
/
Dengue
Type of study:
Diagnostic study
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Cuba
Language:
English
Journal:
J med virol
Year:
2004
Document type:
Article
Institution/Affiliation country:
Ministerio de Salud Pública/Cuba
/
Pedro kourí Tropical Medicine Institute/Cuba
/
Provincial Hospital/Cuba
/
UMDNJ-New Jersey Medical School/Estados Unidos