Virological, immunological, and clinical impact of switching from protease inhibitors to nevirapine or to efavirenz in patients with human immunodeficiency virus infection and long-lasting viral suppression / Impacto virológico, inmunológico y clínico del cambio de inhibidores de proteasa a terapia con nevirapina o efavirenz en pacientes infactados con el VIH que presentan una supresión viral prolongada
Clin Infect Dis
; 34(4)feb. 2002. tab, graf
Article
in English
| CUMED
| ID: cum-39443
Responsible library:
CU425.1
ABSTRACT
Seventy-seven subjects infected with human immunodeficiency virus were randomized to switch from protease inhibitor (PI) therapy to nevirapine therapy (group A; n=26) or to efavirenz therapy (group B; n=25) or to continue PI therapy (group C; n=26), At month 12, viral suppression had been maintained in 96 of patients in group A, 92 of patients in group B, and 92 of patients in group C. A significant increase in the CD4(+) level was observed in all 3 groups, In group A, lipid profiles improved, whereas levels of gamma-glutamiltransferase and alanine aminotransferase significantly increased; 1 subject interrupted treatment because of hepatotoxicity. In group B, an increase in gamma-glutamiltransferase levels was also observed, and 3 patients interrupted treatment because of central nervous system symptoms, Two patients in group C withdrew therapy, Quality of life significantly improved for groups A and B, In patients receiving effective PI-based therapy, the replacement of the PI with either nevirapine or efavirenz is safe and virologically effective(AU)
Full text:
Available
Collection:
National databases
/
Cuba
Database:
CUMED
Main subject:
HIV Infections
/
HIV Protease Inhibitors
/
Nevirapine
/
Antiretroviral Therapy, Highly Active
Type of study:
Controlled clinical trial
Aspects:
Patient-preference
Limits:
Humans
Language:
English
Journal:
Clin Infect Dis
Year:
2002
Document type:
Article
Institution/Affiliation country:
Hospital Universitario Arnaldo Milián Castro/Cuba
/
University Hospital/España