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Linfocitos T CD4+ y carga viral en pacientes VIH/sida de la tercera edad que reciben tratamiento antirretroviral / CD4+ T-lymphocytes and viral load in elderly patients with HIV/AIDS who receive antiretroviral treatment
Hernández Requejo, Daymé; Abad Lamoth, Yoandra; Valle Carvajal, Elizabeth B.
Affiliation
  • Hernández Requejo, Daymé; Instituto de Medicina Tropical Pedro Kourí. La Habana. Cuba
  • Abad Lamoth, Yoandra; Instituto de Medicina Tropical Pedro Kourí. La Habana. Cuba
  • Valle Carvajal, Elizabeth B; Universidad de La Habana. Facultad de Biología. La Habana. Cuba
Rev. cuba. invest. bioméd ; 32(2)abr.-jun. 2013. tab, ilus
Article in Es | CUMED | ID: cum-57020
Responsible library: CU1.1
Localization: CU1.1
RESUMEN
Introducciín: La infección por el virus de inmunodeficiencia humana (VIH) constituye un importante problema de salud. La capacidad funcional del sistema inmune declina gradualmente con el envejecimiento. Objetivo: Demostrar que los pacientes VIH/sida de la tercera edad, tratados con antirretrovirales, presentan disminución de la carga viral y aumento de los linfocitos T CD4+ con el uso del tratamiento. Métodos: Se realizó un estudio observacional prospectivo de corte transversal en 44 pacientes VIH/SIDA pertenecientes al servicio de Medicina del IPK que recibieron tratamiento con diferentes esquemas de antirretrovirales. Resultados: Se observó un incremento medio de linfocitos T CD4+ de 97 cel/ÁL asó como una disminución media de carga viral de 3 583 cp/ÁL después del tratamiento anitrretroviral. Conclusiones: Con este estudio podemos concluir que con el uso de la terapia antirretroviral en los pacientes VIH/sida de la tercera edad aumentaron los linfocitos T CD4+ y disminuyó la carga viral, lo que evidencia la reconstitución inmunológica y el control virológico de estos pacientes(AU)
ABSTRACT
Background: Infection with the Human Immunodeficiency Virus (HIV) is a major health problem. The functional capacity of the immune system gradually declines with aging. Objective: To demonstrate that the elderly patients with HIV/AIDS who follow treatment with antiretroviral drugs present a fall in viral load and a rise in the CD4+ T-lymphocytes with this treatment. Methods: A cross-sectional prospective observational study was conducted in 44 HIV/AIDS patients attended in the Medical Services offered by IPK who received treatment with different antiretroviral schemes. Results: It was observed that there was an average rise of 97 cel/ÁL in the CD4+ T-lymphocytes, as well as an average fall of 3 583 cp/ÁL in viral load after the antiretroviral treatment. Conclusions: With this study, we can conclude that there was a rise in CD4+ T-lymphocytes and a fall in the viral load in the elderly patients with HIV/AIDS who followed treatment with antiretroviral drugs, what evidences the immunological reconstitution and virologic control of these patients with the use of antiretroviral therapy(AU)
Subject(s)
Key words
Full text: 1 Collection: 06-national / CU Database: CUMED Main subject: CD4-Positive T-Lymphocytes / Acquired Immunodeficiency Syndrome / Lymphocyte Count / Anti-Retroviral Agents Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male Country/Region as subject: Caribe / Cuba Language: Es Journal: Rev. cuba. invest. bioméd Year: 2013 Document type: Article
Full text: 1 Collection: 06-national / CU Database: CUMED Main subject: CD4-Positive T-Lymphocytes / Acquired Immunodeficiency Syndrome / Lymphocyte Count / Anti-Retroviral Agents Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Female / Humans / Male Country/Region as subject: Caribe / Cuba Language: Es Journal: Rev. cuba. invest. bioméd Year: 2013 Document type: Article