Respuesta inmunitaria humoral en pacientes con Colitis Ulcerosa / Introduction: Ulcerative colitis is an inflammatory bowel disease. Little is known about its causes, but genetic, environmental, immunological and bacterial factors have been suggested. Objective: Describe the humoral immune response of patients with ulcerative colitis cared for at the Institute of Gastroenterology from January 2014 to April 2015. Methods: A descriptive cross-sectional prospective study was conducted at the Institute of Gastroenterology from January 2014 to April 2015 which included all the patients diagnosed with ulcerative colitis. An evaluation was performed of clinical, endoscopic and histological variables as well as the results of immunological studies. Results: A predominance was found of the female gender, the over-49 age group and white skin. There was also a predominance of alterations in complement components C3 and C4 and immunoglobulin G. Dependence and isolated correlation was observed between the results of immunological variables and the post-diagnosis time of evolution, the Truelove and Witts clinical scale, the degree of colonoscopic and histological activity, and the degree of dysplasia for p < 0.05. Conclusions: Immune response is a predictive factor for good evolution of the disease, but it does not allow to draw an inference about colonoscopic and histological activity. Immune response, on the other hand, is not related to the clinical evaluation scale of Truelove and Witts, the degree of dysplasia, clinical extraintestinal manifestations or post-diagnosis time of evolution

RESUMEN

Introducción: la colitis ulcerosa es una enfermedad inflamatoria intestinal de causa aún poco conocida. Se postulan muchos mecanismos de producción de tipo genético, ambiental, inmunológico, bacteriano.Objetivo: describir la respuesta inmunitaria humoral en pacientes con colitis ulcerosa atendidos en el Instituto de Gastroenterología en el período enero 2014- abril 2015.Métodos: se realizó un estudio descriptivo prospectivo de corte transversal en el Instituto de Gastroenterología, en el período de enero de 2014 a abril de 2015, donde se incluyeron todos los pacientes con diagnóstico de colitis ulcerosa. Se evaluaron variables clínicas, endoscópicas, histológicas y resultado de los estudios inmunológicos.Resultados: predominó el sexo femenino, edad superior a 49 años y blancos; también hubo predominio de alteraciones de complemento C3 y C4 e inmunoglobulina G. Se halló dependencia y correlación aislada entre el resultado de las variables inmunológicas y el tiempo de evolución posdiagnóstico, la escala clínica de Truelove y Witts, el grado de actividad colonoscópica e histológica, así como el grado de displasia para p < 0,05.Conclusiones: la respuesta inmunitaria es un factor predictivo de buena evolución de la enfermedad aunque no permite realizar inferencia sobre la actividad colonoscópica e histológica; además no se encuentra relacionado con la escala de evaluación clínica de Truelove y Witts, el grado de displasia, las manifestaciones clínicas extraintestinales y el tiempo de evolución posdiagnóstico(AU)

ABSTRACT

Introduction: Ulcerative colitis is an inflammatory bowel disease. Little is known about its causes, but genetic, environmental, immunological and bacterial factors have been suggested.Objective: Describe the humoral immune response of patients with ulcerative colitis cared for at the Institute of Gastroenterology from January 2014 to April 2015.Methods: A descriptive cross-sectional prospective study was conducted at the Institute of Gastroenterology from January 2014 to April 2015 which included all the patients diagnosed with ulcerative colitis. An evaluation was performed of clinical, endoscopic and histological variables as well as the results of immunological studies.Results: A predominance was found of the female gender, the over-49 age group and white skin. There was also a predominance of alterations in complement components C3 and C4 and immunoglobulin G. Dependence and isolated correlation was observed between the results of immunological variables and the post-diagnosis time of evolution, the Truelove and Witts clinical scale, the degree of colonoscopic and histological activity, and the degree of dysplasia for p < 0.05.Conclusions: Immune response is a predictive factor for good evolution of the disease, but it does not allow to draw an inference about colonoscopic and histological activity. Immune response, on the other hand, is not related to the clinical evaluation scale of Truelove and Witts, the degree of dysplasia, clinical extraintestinal manifestations or post-diagnosis time of evolution(AU)