Prodromal spinocerebellar ataxia type 2: Prospects for early interventions and ethical challenges
Mov Disord
; 32(5): 708-718, 2017. tab, graf
Article
in English
| CUMED
| ID: cum-76726
Responsible library:
CU422.1
Localization: 422.1
ABSTRACT
The characterization of prodromal stages in neurodegenerative disorders is becoming increasingly important because of the need for early neuroprotective therapies. Research during the past 3 decades in spinocerebellar ataxia type 2 has revealed a large body of evidence suggesting that many disease features precede the manifest cerebellar syndrome, which delineates the prodromal stage of this disorder. This stage is defined by clinical, imaging, and functional criteria, which are supported by early molecular events demonstrated in animal models. Knowledge regarding prodromal spinocerebellar ataxia type 2 provides insight into the mechanisms underlying neurodegeneration from the early stages, which enables the design of promising disease-modifying clinical trials through the identification of the optimum moment to begin the therapies, the appropriate selection of individuals, and the identification of sensitive outcome measures. The management of patients in prodromal spinocerebellar ataxia type 2 may raise ethical dilemmas related to predictive diagnosis and early interventions, which impose new challenges to clinical and therapeutic research (AU)
Full text:
Available
Collection:
National databases
/
Cuba
Database:
CUMED
Main subject:
Evoked Potentials, Auditory, Brain Stem
/
Spinocerebellar Ataxias
/
Early Diagnosis
/
Evoked Potentials, Somatosensory
Limits:
Humans
Language:
English
Journal:
Mov Disord
Year:
2017
Document type:
Article
Institution/Affiliation country:
Centro para la Investigación y Rehabilitación de las Ataxias Hereditarias/Cuba
/
Department of Clinical Neuroscience, Karolinska Universitetssjukhuset/Suecia