Mucinosis folicular secundaria a fotoalergia por captopril / Follicular mucinosis secondary to captopril-induced photoallergy

RESUMEN

El captopril es uno de los inhibidores de la enzima convertidora de la angiotensina que ha sido ampliamente utilizado como antihipertensivo y vasodilatador. Aunque se producen efectos adversos cutáneos en el 10 % de las prescripciones, no existen muchos datos publicados sobre fotosensibilidad. Por otro lado, la mucinosis folicular se ha descrito asociada a numerosos procesos, principalmente linfomas, lupus eritematoso y con menos frecuencia a erupciones fotoinducidas y reacciones a fármacos. Se presenta el caso de una paciente tratada con captopril que desarrolló una erupción en áreas fotoexpuestas. Histológicamente mostró cambios compatibles con mucinosis folicular, con un fotoparche positivo al captopril y con resolución de las lesiones tras retirar el agente hipotensor

ABSTRACT

Captopril is an angiotensin-converting enzyme inhibitor which has been widely used as an antihypertensive agent and vasodilator. Although adverse skin effects occur in 10% of patients prescribed this drug, there is little published data about photosensitivity. On the other hand, follicular mucinosis has been described in association with numerous processes, mainly lymphomas, lupus erythematosus and, less frequently, with photoinduced eruptions and drug reactions. We present the case of a female patient treated with captopril who developed an eruption in photoexposed areas. Histologically, the patient showed changes consistent with follicular mucinosis, with a positive captopril photopatch test and with resolution of the lesions after the antihypertensive agent was withdrawn