Valor pronóstico de la expresión inmunohistoquímica de la proteína Rb en el carcinoma epidermoide de laringe / Pronostical value of the expresion immunohistochemical of the protein Rb in the epidermoide carcinoma of larynx

RESUMEN

En este trabajo hemos estudiado la expresión inmuno-histoquímica de la proteína Rb (G3-245) en una serie de 195 pacientes con cáncer de laringe que fueron diagnosticados, tratados y seguidos durante 5 años en el servicio ORL del Hospital «Virgen de la Salud» (Toledo). En los casos que presentaron metástasis ganglionares analizamos también la expresión de Rb a dicho nivel. Además se analiza el valor pronóstico de la expresión de Rb en este tipo de tumores (desarrollo de recidivas, mortalidad por cáncer de laringe y supervivencia) y estudiamos la posible relación de dicha expresión con otros parámetros clinicopatológicos

ABSTRACT

In this paper we carried out an immunohistochemical study of protein p21WAF1 (EA 10) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain). In the cases with lymph node metastasis; we also studied p21WAF1 expression at this level. Furthermore we have analysed the value of protein p21WAF1 expression as a prognostic factor (tumor recurrence, deads due to cancer and survival (and we evaluate the relationship between p21WAF1 expression and other clinic and pathologic parameters. Keywords p21WAFl Protein. Larynx cancerIn this paper we carried out an immunohistochemical study of bcl-2 protein expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo. Spain). In the cases with lymphonode metastasis we also analysed bcl-2 protein expression at this level. Furthermore we have studied the value of bcl-2 protein expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we analysed the relationship between bcl-2 protein expression and other clinic and pathologic parametersIn this paper we carried out an immunohistochemical study of protein Rb (G3-245) expression in a series of 195 patients with laryngeal carcinoma that were diagnosticated, treated and followed at the Department of Otolaryngology at «Virgen de la Salud» Hospital (Toledo, Spain) for a time of 5 years. In the cases with lymph node metastasis we also studied Rb expression at this level. Furthermore we have analysed the value of Rb expression as a prognostic factor (tumor recurrence, deads due to cancer and survival) and we evaluate the relationship between Rb expression and other clinic and pathologic parameters