Interdisciplinary clinical evaluation of 58 patients with lumbar-vertebral metastases from cervico-uterine cancer
Clin. transl. oncol. (Print)
; 7(10): 432-440, nov. 2005. ilus, tab
Article
in En
| IBECS
| ID: ibc-040801
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
Introduction. Metastases in the vertebrae of patients with cervical cancer (CeCa) can be difficult to diagnose, and the treatment is palliative in many cases. Objectives. The aim of this study was to assess the time required for diagnosis, the lesion's loco-regional extent and the therapeutic schemes applied, in a retrospective series of 58 patients with CeCa and with lumbar spinal metastases. Methods. The cases were studied using an updated interdisciplinary analysis to determine the clinical and radiological variables. This study evaluated the site and extent of bone lesions and correlated these variables with instability of the spine and cord compression. Results. The diagnosis of vertebrae metastases of CeCa required more than 3 months in most cases. Lumbar vertebrae L4 and L5 and specifically the vertebral body were the most-frequently affected sites. Systemic and/or extra-compartmental-extended metastases (MosV4) were observed in 44/58 patients. Radiotherapy was the only option in this group and the palliative effect achieved was minimal, or null. In 14/58 patients there was intra compartmental-extended (MosV2) and extra-compartmental limited (MosV3) single vertebral metastases and the 3 different treatment schemes were administered. In the cases treated with marginal resection of metastases, vertebroplasty plus adjuvant radiotherapy achieved significant palliative effect. Conclusions. In the present series of patients, the diagnosis of metastases of the lumbar vertebrae was late, and the disease was advanced. The results obtained with radiotherapy in advanced stage disease did not improve the quality of life of patients. Metastasectomy was the therapeutic scheme in cases with intermediate stage disease and was the basis of the integrated treatment. We believe that it is necessary to shorten the diagnostic time and to apply a staging system for vertebral metastases so that appropriate individualised selection of interdisciplinary treatment would be facilitated
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Spinal Neoplasms
/
Uterine Cervical Neoplasms
/
Neoplasm Metastasis
Type of study:
Observational study
/
Risk factors
Aspects:
Patient-preference
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2005
Document type:
Article
Institution/Affiliation country:
Hospital de Ortopedia Victorio de la Fuente del IMSS/México
/
Centro Médico Nacional 20 de Noviembre del ISSSTE/México
/
Hospital de Oncología del Centro Médico Siglo XXI del IMM/México
/
Universidad Autónoma Metropolitana/México