A phase II trial of gemcitabine and weekly high-dose 5-fluorouracil in a 48-hour continuous-infusion schedule in patients with advanced pancreatic carcinoma. A study of the Spanish Cooperative Group for Gastrointestinal Tumour Therapy (TTD)
Clin. transl. oncol. (Print)
; 7(11): 493-498, dic. 2005. tab, graf
Article
in En
| IBECS
| ID: ibc-041722
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
Aim. A multi-centred, open-labelled, phase II study containing 46 patients was conducted to evaluate the clinical benefit of gemcitabine (1,400 mg/m2) combined with 5-FU (3 g/m2) in a 48h continuous infusion (CI). Methods. Both drugs were administered on days 1, 8 and 15 of every 4 week cycle in chemotherapy-naïve patients with locally advanced un-resectable metastatic pancreatic carcinoma. The minimum follow-up was 6 months. Results. Clinical benefit response was the primary endpoint and this was achieved by 24.4% of the patients. Quality of life (QoL) improved in 16.6% of patients. Objective response was observed in 7% of the patients. The median progression-free survival (PFS) was 14.4 weeks and the median overall survival (OS) time was 22.7 weeks. One-year survival was 25%. The most frequent grade 3-4 toxicities were neutropenia (45%), mucositis (7.5%) and hyperbilirubinaemia (10.5%). Conclusions. This schedule was not superior in terms of clinical benefit, response rate, PFS and OS than standard gemcitabine treatment
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Pancreatic Neoplasms
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Pyrimidines
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Antineoplastic Combined Chemotherapy Protocols
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Fluorouracil
Aspects:
Patient-preference
Limits:
Adolescent
/
Adult
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Aged
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Female
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Humans
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Male
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2005
Document type:
Article
Institution/Affiliation country:
Complejo Hospitalario Carlos Haya/Spain
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Fundación Jiménez Díaz/Spain
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Hospital Clínic/Spain
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Hospital Clínico/Spain
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Hospital Duran i Reynals/Spain
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Hospital General Universitario de Elche/Spain
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Hospital General de Especialidades Ciudad de Jaén/Spain
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Hospital General de Guadalajara/Spain
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Hospital Nuestra Sra. de la Candelaria/Spain
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Hospital Ramón y Cajal/Spain