Inhaled Insulin as alternative delivery system for subjects with diabetes – A literature review

RESUMEN

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ABSTRACT

Application of insulin via the pulmonary route has been investigated since about eighty years, and the first inhaled insulin preparation might be commercially available soon. This review gives a detailed, tabulated overview of the available literature on the safety and efficacy of inhaled insulin in pre-clinical and clinical trials. Data on the time-action profile of inhaled insulin will be presented as-well as the published effects of inhaled insulin on clinical endpoints such as HbA1c, hypoglycemia, and treatment satisfaction. Additionally, the potential risks of inhaled insulin, in particular concerning insulin antibodies and lung function parameters will be discussed. Thus, the aim of this review is to give the reader sufficient details to assess the risk-benefit ratio of inhaled insulin on their own