Prevention of irinotecan associated diarrhea by intestinal alkalization. A pilot study in gastrointestinal cancer patients
Clin. transl. oncol. (Print)
; 8(3): 208-212, mar. 2006. tab
Article
in En
| IBECS
| ID: ibc-047656
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
No disponible
ABSTRACT
Aim and background. Intestinal alkalization couldprevent irinotecan associated diarrhea modulatingsome chemical equilibria between irinotecan metabolites.The aim of this study was to evaluate the efficacyof this procedure in advanced gastrointestinalcancer patients (GICP).Materials and method. In this prospective studyadvanced GICP, receiving irinotecan based chemotherapyregimens, were well trained to add sodiumbicarbonate to the water intake in order to accomplishintestinal alkalization.Results. A total of twenty four advanced GICP wereenrolled. Grade III-IV diarrhea has been observedin four patients (16%), some of whom had severalrisk factors for diarrhea. Only one out of seventeencolorectal cancer patients, receiving the irinotecancombination as first line therapy, had grade III-IVdiarrhea. No side effects of the procedure have beenappreciated.Conclusions. Intestinal alkalization may be effectiveas a preventive treatment for irinotecan associateddiarrhea in chemotherapy regimens used in GICP.This procedure deserves further investigation
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Collection:
National databases
/
Spain
Health context:
SDG3 - Health and Well-Being
/
Neglected Diseases
Health problem:
Target 3.3: End transmission of communicable diseases
/
Target 3.4: Reduce premature mortality due to noncommunicable diseases
/
Diarrhea
/
Neglected Diseases
Database:
IBECS
Main subject:
Camptothecin
/
Diarrhea
Type of study:
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clin. transl. oncol. (Print)
Year:
2006
Document type:
Article
Institution/Affiliation country:
Hospital Arnau de Vilanova/Spain
/
Hospital Dr Josep Trueta/Spain
/
Hospital Son Dureta. Palma de Mallorca/Spain
/
Hospital Verge de la Cinta. Tortosa/Spain
/
Hospital de Sant Joan. Reus/Spain
/
Universitat Rovira i Virgili/Spain