Estabilidad de NT-proBNP en pacientes con insuficiencia cardiaca sistólica / Stability of NT-ProBNP in patients with systolic heart failure
Rev. esp. cardiol. (Ed. impr.)
; 59(10): 1075-1078, oct. 2006. tab, graf
Article
in Es
| IBECS
| ID: ibc-049906
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
Los péptidos natriuréticos tienen un alto valor diagnóstico y pronóstico en pacientes con insuficiencia cardiaca, pero desconocemos la estabilidad de sus valores. Determinamos en 2 visitas ambulatorias los valores de N terminal pro-BNP (NT-proBNP) de 30 pacientes consecutivos con insuficiencia cardiaca estable [New York Heart Association (NYHA) II-III] (test 6 min) por disfunción sistólica [función ventricular izquierda deprimida (FEVI) < 30%] separadas entre sí 3 meses. Tenían una edad media de 62,6 ± 12,2 años y una fracción de eyección del 24,2 ± 6,68%. No encontramos diferencias significativas entre los valores basales del NT-proBNP como test de los 6 min (2.237,3 pg/ml y 348,26 m) y a los 3 meses (2.096,2 pg/ml y 372,05 m). El coeficiente de correlación intraclase entre los valores basales y a los 3 meses de NT-proBNP fue de 0,94 (p < 0,001). Existe una buena correlación entre los valores basales y a los 3 meses de las concentraciones plasmáticas de NT-proBNP en pacientes con insuficiencia cardiaca crónica estable (NYHA II-III) por disfunción sistólica
ABSTRACT
Natriuretic peptides are extremely useful in the diagnosis and prognosis of patients with heart failure. However, it is not clear whether their values are stable. We carried out a prospective study of 30 consecutive ambulatory patients (mean age, 62.6 [12.2] years) with stable systolic heart failure, as determined by the 6-minute walk test, who were in New York Heart Association class II or III and who had a left ventricular ejection fraction <30% (mean ejection fraction, 24.2% [6.68%]). At baseline, the mean N-terminal pro-brain natriuretic peptide (NT-proBNP) level and the mean distance walked in 6 minutes were 2237.3 pg/mL and 348.26 m, respectively. At 3-month follow-up, the corresponding values were 2096.2 pg/mL and 372.05 m, respectively. No significant difference was observed in NT-proBNP level or in distance walked in 6 minutes between baseline and 3 months (P=.8). Overall, there was a good correlation (r=0.94; P<.001) between the plasma NT-proBNP level at baseline and at 3 months in patients with stable chronic heart failure due to systolic dysfunction in New York Heart Association class II or III
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Cardiac Output, Low
/
Natriuretic Peptide, Brain
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. esp. cardiol. (Ed. impr.)
Year:
2006
Document type:
Article
Institution/Affiliation country:
Hospital Clínico Universitario Virgen de la Victoria/España