Estudio epidemiológico de la psoriasis inducida por fármacos / An epidemiological study of psoriasis induced by drugs

RESUMEN

Objetivo. La hipótesis de trabajo es la de demostrar una asociación genética de la psoriasis inducida por fármacos. Material y métodos. 114 casos con psoriasis vulgar (61 hombres y 53 mujeres). Se registró (1) antecedentes familiares de psoriasis; (2) otras enfermedades; (3) fármacos referidas en la bibliografía como inductoras de psoriasis y que se demuestran como tales en la población estudiada; y (4) que exacerbaron la psoriasis. Análisis de la distribución por edad de inicio de la psoriasis, antecedente familiar y psoriasis inducida por fármacos. Resultados. 28/114 casos (24,56 %) iniciaron su psoriasis luego de la administración de fármacos. 6/35 casos (17,14 %) con antecedentes familiares y 22/79 casos (27,84 %) sin antecedentes familiares (X2 = 0,98 p > 0,05). La aparición de psoriasis inducida por fármacos ocurrió en (1) 1/56 30 años (X2 = 17,56 p 30 años sin antecedentes familiares (X2 = 12,64 p 30 años con antecedentes familiares (X2 = 3,18 p > 0,05). La edad de inicio es mayor en los casos de psoriasis inducida por fármacos (51,42±13,06 años) comparado a la que no se vincula a fármacos (26,55±12,77 años), p < 0,001. Conclusiones. La psoriasis inducida por fármacos no depende de una condición genética o heredable, sugiriendo que es debida a una alteración bioquímica

ABSTRACT

Objective. The hypothesis is the demonstration of a genetic association for the psoriasis induced by drugs. Material and methods. One hundred and fourteen cases with psoriasis vulgaris (61 men and 53 women). The data for analysis was (1) family background of psoriasis; (2) others illnes; (3) drugs referred in the bibliography to induce psoriasis and that they are demonstrated as such in the studied population; and (4) drugs that exacerbated the psoriasis. Analysis of the distribution by age of beginning the psoriasis, sex, family background and psoriasis induced by drugs. Results. Twenty eight out of 114 cases (24,56%) began their psoriasis after the administration of drugs. Six out of 35 cases (17,14%) with family background and 22 out of 79 cases (27,84%) without family background(X2 = 0,98 p > 0,05). The beginning of psoriasis induced by drugs was (1) 1/56 30 years-old (X2 = 17,56 p 30 years-old without family background (X2 = 12,64 p 30 years-old with family background (X2 = 3,18 p > 0,05). The beginning age is over in the cases with psoriasis induced by drugs (51,42±13,06 years-old) compared with the one that is not linked to drugs (26,55±12,77 years-old), p < 0,001. Conclusions. The psoriasis induced by drugs does not depend on a genetic or inheritable condition, suggesting that it is due to a biochemical alteration