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Lesion Location in Depression Post Traumatic Brain Injury Using Magnetic Resonance Spectroscopy: Preliminary Results from a Pilot Study
Rao, Vani; Spiro, Jennifer; Degoankar, Mahaveer; Horská, Alena; Rosenberg, Paul B; Yousem, David M; Barker, Peter B; Phil, D.
Affiliation
  • Rao, Vani; Johns Hopkins School of Medicine. Department of Psychiatry. Division of Geriatric Psychiatry & Neuropsychiatry. Baltimore. USA
  • Spiro, Jennifer; Johns Hopkins School of Medicine. Department of Psychiatry. Division of Geriatric Psychiatry & Neuropsychiatry. Baltimore. USA
  • Degoankar, Mahaveer; Johns Hopkins School of Medicine. Department of Radiology and Radiological Science. Baltimore. USA
  • Horská, Alena; Johns Hopkins School of Medicine. Department of Radiology and Radiological Science. Baltimore. USA
  • Rosenberg, Paul B; Johns Hopkins School of Medicine. Department of Psychiatry. Division of Geriatric Psychiatry & Neuropsychiatry. Baltimore. USA
  • Yousem, David M; Johns Hopkins School of Medicine. Department of Radiology and Radiological Science. Baltimore. USA
  • Barker, Peter B; Johns Hopkins School of Medicine. Department of Radiology and Radiological Science. Baltimore. USA
  • Phil, D; s.af
Eur. j. psychiatry ; 20(2): 65-73, abr.-jun. 2006. ilus, tab
Article in En | IBECS | ID: ibc-054520
Responsible library: ES1.1
Localization: ES1.1 - BNCS
RESUMEN
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ABSTRACT

Objective:

To determine the metabolic status of the brain in post traumatic brain injury(TBI) depression using proton magnetic resonance spectroscopy (MRS).

DESIGN:

Case-control study including 5 TBI depressed subjects and 5 age matched non-TBI non-depressed controls.

Methods:

Metabolic status was assessed using proton MRS. Ratios of N-acetylaspartate (NAA), choline (Cho) and total creatine (Cr) were calculated in frontal cortex, basal ganglia and thalamus.

Results:

NAA/Cho or NAA/Cr ratios were significantly reduced in the TBI depressed group compared to controls in frontal cortex, basal ganglia and thalamus.

Conclusion:

Reduced levels of NAA in frontal regions, basal ganglia and thalamus in TBI depression suggest neuronal damage or dysfunction which may be a associated with the primary brain injury or with depressed mood (AU)
Subject(s)
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Stress Disorders, Post-Traumatic / Depressive Disorder / Brain Injuries, Traumatic Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Eur. j. psychiatry Year: 2006 Document type: Article Institution/Affiliation country: Johns Hopkins School of Medicine/USA
Fulltext
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Full text: Available Collection: National databases / Spain Database: IBECS Main subject: Stress Disorders, Post-Traumatic / Depressive Disorder / Brain Injuries, Traumatic Type of study: Observational study / Risk factors Limits: Humans Language: English Journal: Eur. j. psychiatry Year: 2006 Document type: Article Institution/Affiliation country: Johns Hopkins School of Medicine/USA