Síndrome atípico de Cogan. Espectro clínico y de laboratorio. Presentación de dos casos / Atypical Cogan's syndrome. Clinical features and laboratory findings. Report of two cases
Acta otorrinolaringol. esp
; 53(3): 191-198, mar. 2002. ilus, graf, tab
Article
in Es
| IBECS
| ID: ibc-10396
Responsible library:
ES1.1
Localization: ES1.1 - BNCS
RESUMEN
Exponemos dos casos de presentación atípica de síndrome de Cogan en sendos individuos de 47 y 56 años de edad. En ambos se detecta la sintomatología característica del síndrome (queratitis intersticial, hipoacusia neurosensorial y vértigo), pero la asociación de trastornos generales y el inicio del cuadro por su deterioro audiovestibular los hacen infrecuentes. Los dos casos evidenciaron elevaciones en la VSG y niveles de inmunoglobulinas, y títulos positivos de factor de reumatoide y autoanticuerpos inespecíficos. Mediante un test de Western-blot pudieron determinarse anticuerpos contra antígenos clocleares de distinto peso molecular, siendo común el de 68 KD.El tratamiento de metil-prednisolona no evitó nuevas recidivas oftálmicas y auditivas en uno de los dos pacientes. (AU)
ABSTRACT
We show two atypical Cogan's syndrome cases in forty-seven and fifty-six years old individuals. Characteristical symptoms of the syndrome were detected in both (interstitial keratitis, sensorineural deafness and vestibular dysfunction), but they could be considered as unusual because of the association of systematic symptoms and an onset with hearing loss. In both cases there was an increase in erythrosedimentation rate and immunoglobulins levels, as well as high titles for rheumatoid factor and non-specific autoantibodies. By means of a Western-blot technique, several chochlear antibodies with distinct molecular weight were detected, but the 68 KD appeared in both. Metil-prednisolone treatment did not avoid ocular and auditive reactivation in one of the patients (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Vertigo
/
Hearing Loss
/
Keratitis
Type of study:
Diagnostic study
Limits:
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Acta otorrinolaringol. esp
Year:
2002
Document type:
Article
Institution/Affiliation country:
Hospital Cínico Universitario/España