Immunohistochemical expression of Skp2 protein in oral nevi and melanoma
Med. oral patol. oral cir. bucal (Internet)
; 18(3): 388-391, mayo 2013. ilus
Article
in English
| IBECS
| ID: ibc-112697
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Objective:
The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oralnevi and 11 primary oral melanomas. StudyDesign:
Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocyticlesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting1000 cells per slide.Results:
Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showedhigh levels of this protein.Conclusion:
These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
SKP Cullin F-Box Protein Ligases
/
Melanoma
/
Nevus
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2013
Document type:
Article
Institution/Affiliation country:
University of São Paulo (USP)/Brazil
/
Centro Clínico de Cabeza y Cuello/ Guatemala
/
Universidad Autónoma Metropolitana Xochimilco/México
/
Universidad Peruana Cayetano Heredia/Perú
/
University of Campinas (UNI-CAMP)/Brazil
/
University of Campinas (UNI¬CAMP)/Brazil