Tratamiento antiangiogénico en fondo de distrofia de Sorsby sin mutación en gen de TIMP-3 / Antiangiogenic therapy in Sorsby's fundus dystrophy without a mutation in the TIMP-3 gene
Arch. Soc. Esp. Oftalmol
; 88(6): 240-243, jun. 2013. ilus
Article
in Spanish
| IBECS
| ID: ibc-113285
Responsible library:
ES1.1
Localization: BNCS
RESUMEN
Caso clínico Varón de 32 años, con metamorfopsias y visión borrosa bilateral de tres días de evolución. Mejor agudeza visual corregida de 20/32 en OD y 20/25 en OI. La funduscopia presenta lesiones amarillentas difusas sugerentes de distrofia de Sorsby y membranas neovasculares (MNV). Recibió tratamiento con ranibizumab intravítreo, mejorando la agudeza visual a 20/20 en ambos ojos y remitiendo las MNV. No se hallaron mutaciones conocidas de TIMP-3. Discusión:
Las mutaciones conocidas en TIMP-3 pueden no estar extendidas a todos los pacientes con fondo de distrofia de Sorsby. El ranibizumab intravítreo debe considerarse para el tratamiento de MNV secundaria a esta enfermedad (AU)ABSTRACT
Case report The case is presented of a 32-year-old man referring to metamorphopsia and blurred vision in both eyes for 3 days. Best corrected visual acuity of 20/32 in the right eye and 20/25 in the left eye. Fundus examination revealed the presence of drusen-like deposits, suggestive of Sorsby's fundus dystrophy (SFD) and choroidal neovascularization (CNV) bilaterally. The patient received intravitreal ranibizumab. Visual acuity improved to 20/20 in both eyes at 6-months follow-up, and results of fundus examination showed complete regression of neovascularization. No mutations were found in the TIMP-3 gene. Discussion:
The known mutations in TIMP-3 may not be extended to all patients with SFD. The use of intravitreal ranibizumab may be considered as a therapeutic option in CNV secondary to SFD (AU)
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Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Corneal Neovascularization
/
Tissue Inhibitor of Metalloproteinase-3
/
Angiogenesis Inhibitors
Limits:
Adult
/
Humans
/
Male
Language:
Spanish
Journal:
Arch. Soc. Esp. Oftalmol
Year:
2013
Document type:
Article
Institution/Affiliation country:
Complejo Hospitalario Universitario de Albacete/España