Burkitts lymphoma of the jaws in the Amazon region of Brazil
Med. oral patol. oral cir. bucal (Internet)
; 19(1): e32-e38, ene. 2014. ilus, tab
Article
in English
| IBECS
| ID: ibc-118250
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
OBJECTIVES:
To describe the clinicopathologic and immunohistochemical features of Burkitt's lymphoma of the jaws in 7 patients of Northern Brazil. StudyDESIGN:
Clinical data concerning gender, age, affected site, clinical presentation, symptomatology and follow-up were collected from the clinical files. Histopathology was complemented with a broad immunohistochemical panel and in situ hybridization for Epstein-Barr virus (EBV).RESULTS:
Most of the patients were infants and 5 out of 7 were males. The mandible was affected in 5 cases and all patients also presented abdominal involvement. All cases were positive for CD45, CD20, CD79a, CD10, Bcl-6 and EBV. Ki-67 proliferative index was approximately 100%. Six patients were treated with R-CHOP (Rituximab + Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone) chemotherapy, and 2 of these died of the disease. One young adult patient refused treatment and died 3 months after initial diagnosis.CONCLUSIONS:
Burkitt's lymphoma of the jaws diagnosed in the Amazon region of Brazil present similar clinico-pathologic features to those described in endemic areas of Africa, including EBV positivityRESUMEN
No disponible
Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Mandibular Neoplasms
/
Burkitt Lymphoma
Limits:
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Med. oral patol. oral cir. bucal (Internet)
Year:
2014
Document type:
Article
Institution/Affiliation country:
Federal University of Pará/s. p
/
State University of Campinas/Brazil
/
University of São Paulo/Brazil