Double-balloon enteroscopy in the management of patients with Peutz-Jeghers syndrome: a retrospective cohort multicenter study / Enteroscopia de doble balón en el tratamiento de paciente con síndrome de Peutz-Jeghers: un estudio multicéntrico de cohorte retrospectiva
Rev. esp. enferm. dig
; 105(10): 594-599, nov.-dic. 2013. tab, ilus
Article
in English
| IBECS
| ID: ibc-119287
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
Background and objective:
Little is known about the clinical impact of double-balloon enteroscopy (DBE) in patients with Peutz- Jeghers syndrome (PJS). The aim of this study was to assess the efficacy and safety of DBE in the management of small-bowel polyps in PJS patients. Patients andmethods:
We conducted a multicentre, retrospective cohort study, which included all consecutive patients diagnosed with PJS who underwent DBE for polypectomy between January 2006 and August 2012. In all cases, previous videocapsule enteroscopy had shown at least one polyp ≥ 10 mm in size.Results:
Twenty-five patients (13 men; median age 36 years; 14 with prior laparotomy) underwent 46 DBE procedures (1 to 5 per patient, 44 via oral route). Polypectomy was performed in 39/46 DBEs. A total of 214 polyps were removed (median-size 30 mm), with a median number of polypectomies per procedure of 5.0 (range 1-18). The estimated maximum-sizes of resected polyps significantly decreased at each session 30.0, 25.0, 20.0, 15.0, and 17.5 mm (p = 0.02). In 7 DBEs no polypectomy was performed (4-only minor polyps detected; 3-endoscopic irresecability). Complications occurred in 3/39 of therapeutic procedures (2-minor delayed bleeding; 1-mucosal tear), all of them dealt with conservative or endoscopic therapy. Six patients underwent elective surgery post DBE due to polyps not amenable for endoscopic resection. There were no small-bowel polyp related complications during a median follow-up of 56.5 months.Conclusion:
DBE showed to be a safe and effective technique in the management of small-bowel polyps in PJS patients, allowing a presymptomatic and non-surgical approach (AU)RESUMEN
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Full text:
Available
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Peutz-Jeghers Syndrome
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Intestinal Polyps
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Double-Balloon Enteroscopy
Type of study:
Controlled clinical trial
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Etiology study
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Observational study
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Risk factors
Limits:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
Language:
English
Journal:
Rev. esp. enferm. dig
Year:
2013
Document type:
Article
Institution/Affiliation country:
Centro Hospitalar e Universitário de Coimbra (HUC)/Portugal
/
Hospital Geral de Santo António (HGSA), E.P.E/Portugal
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Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), E.P.E/Portugal
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ManopH Laboratório de Endoscopia e Motilidade Digestiva/Portugal