Diagnostic usefulness of component-resolved diagnosis by skin prick tests and specific IgE to single allergen components in children with allergy to fruits and vegetables
Allergol. immunopatol
; 42(2): 127-135, mar.-abr. 2014. tab
Article
in English
| IBECS
| ID: ibc-121011
Responsible library:
ES1.1
Localization: BNCS
ABSTRACT
INTRODUCTION:
The accurate identification of sensitizing proteins in patients allergic to plant-derived foods is extremely important, allowing a correct dietary advice. We aimed to evaluate the diagnostic usefulness of skin prick tests (SPT) and specific IgE (sIgE) with single molecular allergen components in children with allergy to fruits and vegetables.METHODS:
Twenty children underwent SPT with a palm profilin (Pho d 2, 50 μg/mL); a Mal d 1-enriched apple extract (2 μg/mL) (PR-10 allergen); and a peach Lipid Transfer Protein (LTP) (Pru p 3, 30 μg/mL). Detection of sIgE to rBet V 1, rBet V 2, Phl p 12 and Pru p 3 was also measured.RESULTS:
Allergy to multiple fruits and vegetables was observed in 11 (55%) children. Sensitization by SPT to Pho d 2, Mal d 1, and Pru p 3 occurred in 5, 7, and 8 cases, respectively. LTP sensitization appeared to be associated with peach allergy but not with severe reactions, and profilins sensitization to melon and tomato allergy. Kiwi sensitization (12 cases), the plant-derived food that caused more allergic reactions, seemed mostly species-specific. The concordance of SPT extracts and sIgE to the corresponding pan-allergens was high for profilins (k = 0.857) and LTP (k = 0.706), while for PR-10 allergens it was absent (k = 0.079).CONCLUSIONS:
Pan-allergen sensitization in children with allergy to fruits and vegetables was common and often multiple. There was no association of severe reactions to LTP sensitization. The introduction of routine SPT to pan-allergens can be a simple and feasible way of improving diagnostic and therapeutic efficacyRESUMEN
No disponible
Search on Google
Collection:
National databases
/
Spain
Database:
IBECS
Main subject:
Skin Tests
/
Food Hypersensitivity
/
Hypersensitivity, Immediate
Type of study:
Diagnostic study
/
Evaluation study
/
Prognostic study
Limits:
Child
/
Female
/
Humans
/
Male
Language:
English
Journal:
Allergol. immunopatol
Year:
2014
Document type:
Article
Institution/Affiliation country:
Centro Hospitalar do Porto/Portugal