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Bone remodelling is reduced by recovery from iron-deficiency anaemia in premenopausal women
Wright, Ione; Blanco-Rojo, Ruth; Toxqui, Laura; Pérez-Granados, Ana M; Vaquero, M Pilar; Fernández, M Cristina; Moreno, Gemma; Remacha, Ángel F; Piedra, Concepción de la.
Affiliation
  • Wright, Ione; Spanish National Research Council (CISC). Technology and Nutrition (ICTAN). Institute of Food Science. Madrid. Spain
  • Blanco-Rojo, Ruth; Spanish National Research Council (CISC). Technology and Nutrition (ICTAN). Institute of Food Science. Madrid. Spain
  • Toxqui, Laura; Spanish National Research Council (CISC). Technology and Nutrition (ICTAN). Institute of Food Science. Madrid. Spain
  • Pérez-Granados, Ana M; Spanish National Research Council (CISC). Technology and Nutrition (ICTAN). Institute of Food Science. Madrid. Spain
  • Vaquero, M Pilar; Spanish National Research Council (CISC). Technology and Nutrition (ICTAN). Institute of Food Science. Madrid. Spain
  • Fernández, M Cristina; Complejo Hospitalario de Toledo. Toledo. Spain
  • Moreno, Gemma; Complejo Hospitalario de Toledo. Toledo. Spain
  • Remacha, Ángel F; Complejo Hospitalario de Toledo. Toledo. Spain
  • Piedra, Concepción de la; Fundación Jiménez Díaz Institute for Medical Research (IIS-FJD). Department of Biochemistry Investigation. Madrid. Spain
J. physiol. biochem ; 69(4): 889-896, dic. 2013.
Article in English | IBECS | ID: ibc-121646
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
Iron-deficiency anaemia (IDA), one of the most common and widespread health disorders worldwide, affects fundamental metabolic functions and has been associated with deleterious effects on bone. Our aim was to know whether there are differences in bone remodelling between a group of premenopausal IDA women and a healthy group, and whether recovery of iron status has an effect on bone turnover markers. Thirty-five IDA women and 38 healthy women (control group) were recruited throughout the year. IDA women received pharmacological iron treatment. Iron biomarkers, aminoterminal telopeptide of collagen I (NTx), procollagen type 1 N-terminal propeptide (P1NP), 25-hydroxyvitamin D, and parathormone (PTH) were determined at baseline for both groups and after treatment with pharmacological iron for the IDA group. IDA subjects were classified as recovered (R) or non-recovered (nR) from IDA after treatment. NTx levels were significantly higher (p <0.001), and P1NP levels tended to be lower in IDA women than controls after adjusting for age and body mass index (BMI), with no differences in 25-hydroxyvitamin D or PTH. After treatment, the R group had significantly lower NTx and P1NP levels compared to baseline (p <0.05 and p <0.001 respectively), whilst no significant changes were seen in the nR group. No changes were seen in 25-hydroxyvitamin D or PTH for either group. IDA is related to higher bone resorption independent of age and BMI. Recovery from IDA has a concomitant beneficial effect on bone remodelling in premenopausal women, decreasing both bone resorption and formation (AU)
Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: 16595 / Bone Remodeling / Anemia, Iron-Deficiency Type of study: Observational study / Risk factors Limits: Female / Humans Language: English Journal: J. physiol. biochem Year: 2013 Document type: Article Institution/Affiliation country: Complejo Hospitalario de Toledo/Spain / Fundación Jiménez Díaz Institute for Medical Research (IIS-FJD)/Spain / Spanish National Research Council (CISC)/Spain
Search on Google
Collection: National databases / Spain Database: IBECS Main subject: 16595 / Bone Remodeling / Anemia, Iron-Deficiency Type of study: Observational study / Risk factors Limits: Female / Humans Language: English Journal: J. physiol. biochem Year: 2013 Document type: Article Institution/Affiliation country: Complejo Hospitalario de Toledo/Spain / Fundación Jiménez Díaz Institute for Medical Research (IIS-FJD)/Spain / Spanish National Research Council (CISC)/Spain
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