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Effect of some pyrimidine compounds on rat brain monoamine oxidase-B in vitro
Shaban, Nadia Z; Mawlawi , Mai A; Awad , Doaa; Sadek, Omayma M; Masoud , Mamdouh S.
Affiliation
  • Shaban, Nadia Z; Alexandria University. Faculty of Science. Biochemistry Department. Alexandria. Egypt
  • Mawlawi , Mai A; Alexandria University. Faculty of Science. Biochemistry Department. Alexandria. Egypt
  • Awad , Doaa; Alexandria University. Faculty of Science. Biochemistry Department. Alexandria. Egypt
  • Sadek, Omayma M; Alexandria University. Faculty of Science. Biochemistry Department. Alexandria. Egypt
  • Masoud , Mamdouh S; Alexandria University. Faculty of Science. Chemistry Department. Alexandria. Egypt
J. physiol. biochem ; 68(4): 475-484, dic. 2012. ilus
Article in English | IBECS | ID: ibc-122296
Responsible library: ES1.1
Localization: BNCS
ABSTRACT
The effects of some pyrimidine compounds (PCs) including barbituric acid (BA) 5,5-diethyl barbituric acid (DEBA), 2-thiobarbituric acid (TBA), violuric acid (VA), 2-thiouracil (TU), and 6-amino-2-thiouracil (ATU) on the activity of rat brain monoamine oxidase-B (MAO-B) were investigated. The results revealed that MAO-B was activated by BA, DEBA, TBA, TU, and ATU, and the activation was structural, concentration, and time dependent. However, MAO-B was inhibited by VA in a noncompetitive and irreversible manner with an enzyme-inhibitor dissociation constant (K i value) of 32 nM and IC50 equals to 19 nM. All the studied PCs changed both the optimum pH and temperature of MAO-B (AU)
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Collection: National databases / Spain Database: IBECS Main subject: Pyrimidines / Cerebrum / Monoamine Oxidase Limits: Animals Language: English Journal: J. physiol. biochem Year: 2012 Document type: Article Institution/Affiliation country: Alexandria University/Egypt
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Collection: National databases / Spain Database: IBECS Main subject: Pyrimidines / Cerebrum / Monoamine Oxidase Limits: Animals Language: English Journal: J. physiol. biochem Year: 2012 Document type: Article Institution/Affiliation country: Alexandria University/Egypt