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Lipid peroxidation, antioxidant activities and stress protein (HSP72/73, GRP94) expression in kidney and liver of rats under lithium treatment
Nciri, Riadh; Allagui, Mohamed Salah; Bourogaa, Ezzedine; Saoudi, Monji; Elfeki, Abdelfettah; Murat, Jean-Claude; Croute, Françoise.
Affiliation
  • Nciri, Riadh; Faculté des Sciences. Laboratoire d’écophysiologie. Sfax. Tunisia
  • Allagui, Mohamed Salah; Faculté des Sciences. Laboratoire d’écophysiologie. Sfax. Tunisia
  • Bourogaa, Ezzedine; Faculté des Sciences. Laboratoire d’écophysiologie. Sfax. Tunisia
  • Saoudi, Monji; Faculté des Sciences. Laboratoire d’écophysiologie. Sfax. Tunisia
  • Elfeki, Abdelfettah; Faculté des Sciences. Laboratoire d’écophysiologie. Sfax. Tunisia
  • Murat, Jean-Claude; Université Toulouse III. Faculté de Médecine. Laboratoire de Biologie cellulaire et Pollution. Toulouse. France
  • Croute, Françoise; Université Toulouse III. Faculté de Médecine. Laboratoire de Biologie cellulaire et Pollution. Toulouse. France
J. physiol. biochem ; 68(1): 11-18, mar. 2012.
Article in English | IBECS | ID: ibc-122373
Responsible library: ES1.1
Localization: BNCS
RESUMEN
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ABSTRACT
The present work was aimed at studying the effects of a subchronic lithium treatment on rat liver and kidneys, paying attention to the relationship between lithium toxicity, oxidative stress, and stress protein expression. Male rats were submitted to lithium treatment by adding 2 g of lithium carbonate/kg of food for different durations up to 1 month. This treatment led to serum concentrations ranging from 0.5 mM (day 7) to 1.34 mM (day 28) and renal insufficiency highlighted by an increase of blood creatinine and urea levels and a decrease of urea excretion. Lithium treatment was found to trigger an oxidative stress both in kidney and liver, leading to an increase of lipid peroxidation level (TBARS) and of superoxide dismutase and catalase activities. Conversely, glutathione peroxidase activity was reduced. Constitutive HSP73 (heat shock protein 73) expression was not modified by lithium treatment, whereas inducible HSP72 was down-regulated in kidney. GRP94 (glucose regulated protein 94) appeared as two isoforms of 92 and 98 kDa the 98-kDa protein being overexpressed in kidney by lithium treatment whereas 92-kDa protein was underexpressed both in kidney and liver (AU)
Subject(s)
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Collection: National databases / Spain Database: IBECS Main subject: Lipid Peroxidation / Glucose Transport Proteins, Facilitative / HSP72 Heat-Shock Proteins / Kidney / Lithium / Liver Limits: Animals Language: English Journal: J. physiol. biochem Year: 2012 Document type: Article Institution/Affiliation country: Faculté des Sciences/Tunisia / Université Toulouse III/France
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Collection: National databases / Spain Database: IBECS Main subject: Lipid Peroxidation / Glucose Transport Proteins, Facilitative / HSP72 Heat-Shock Proteins / Kidney / Lithium / Liver Limits: Animals Language: English Journal: J. physiol. biochem Year: 2012 Document type: Article Institution/Affiliation country: Faculté des Sciences/Tunisia / Université Toulouse III/France
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